Driving down the road at 60 mph and the car starts to shake and has no power. It first threw a p0303, take it off the wrecker and drive it up the driveway and get the p2293. The only thread I can find with these 2 codes is an older and different model audi. Read his last post. https://www.audiforums.com/forum/b8-models-72/shuddering-spewing-smoke-now-wont-start-217211/
I was thinking he got the second code due to the ecu cutting fuel because of the miss fire. Has anyone else had this issue and was it the same fix?

 

Hello
I have similar problem.

Audi A4 Avant (8K5, B8) 2.0 TFSI flexible fuel quattro.
I had problems with it last summer it stopped working completely. I read of the code and the engine was P2293 and P0303
P0303 - Cylinder # 3 misfire
P2293 - Fuel Pressure Regulator 2 Performance
I change the petrol pump 2 and all ignition coils and spark plugs. After it has gone well until yesterday. It started to go bad just like before I had switched the ignition coil and spark plugs (only went on 3 cylinders). I read the engine code again and it is just the same fault codes P2293 and P0303. After that I have the old ignition coils so I tried to switch to them, and even spark but there will be no distinction it is only 3 cylinders. The spark plug is wet of gasoline and exhaust white smoke and it smells a little gasoline on the exhaust.

Have you fixed your problem and what was it ??